Gaboxadol (hydrochloride)

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Gaboxadol (盐酸盐) 是一种 GABAA 受体激动剂。

Gaboxadol (hydrochloride) is a GABAA receptor agonist.(In Vitro):Gaboxadol hydrochloride (0.34, 3.5 and 7.0 μM) decreses permeability across Caco-2 cell monolayers with a dose dependent manner, shows the mean Papp values with 8.1 × 10-6 cm·s-1, 6.1 × 10-1 cm·s-6 and 5.6 × 10-6 cm·s-1 for 0.34, 3.5 and 7 μM gaboxadol, respectively.(In Vivo):Gaboxadol hydrochloride (intraperitoneal injection; 0.5, 1, 1.5, 2, 3, 4, or 5 mg/kg; once daily; three-day interval) normalizes the distance traveled by Fmr1 KO2 mice to WT activity levels at 0.5 mg/kg, additionally, this compound has no effect on locomotor activity in Fmr1 KO2 mice.

Gaboxadol hydrochloride (0.34, 3.5 and 7.0 μM) decreses permeability across Caco-2 cell monolayers with a dose dependent manner, shows the mean Papp values with8.1 × 10-6 cm·s-1, 6.1 × 10-1 cm·s-6 and 5.6 × 10-6 cm·s-1 for 0.34, 3.5 and 7 μM gaboxadol, respectively.

Gaboxadol hydrochloride (intraperitoneal injection; 0.5, 1, 1.5, 2, 3, 4, or 5 mg/kg; once daily; three-day interval) normalizes the distance traveled by?Fmr1?KO2 mice to WT activity levels at 0.5?mg/kg, additionally, this compound has no effect on locomotor activity in?Fmr1?KO2 mice. Animal Model:Fmr1?KO2 mice (deletion of the promoter and first exon of?Fmr1?resulting in mRNA and protein null mice) Dosage:0.5, 1, 1.5, 2, 3, 4, or 5 mg/kg Administration:Intraperitoneal injection Result:Normalized Hyperactivity Observed in?Fmr1?KO2 mice.

Lu 02-030 (hydrochloride) | THIP (hydrochloride)

Others

Other Targets

GABA

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85118-33-8

176.6

C6H9ClN2O2

>98% (HPLC)

DMSO:75 mg/mL (424.69 mM)

Cl.O=c1[nH]oc2c1CCNC2

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(-20℃)

With Ice Pack

≥ 2 years